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Glutathione (GSH) is the most abundant antioxidant in the body 6 and one of the most concentrated metabolites in the cell 7
Liraglutide has been shown to ameliorate this lipid droplet accumulation in ARPE-19 cells by activating the AMP-activated protein kinase (AMPK) pathway, which in turn attenuates EMT, enhances lipophagy, and mitigates oxidative stress [67]
This hypothesis is consistent with the idea that glutathione is a mechanism for cysteine storage [12], but also helps explain the reason for the -glutamyl cycle and the reason for the short half-life of hepatic GSH
As with any new drug, long-term studies are incomplete and we do not know all of the possible long-term side effects and health impacts of their use
10 Anti-lipid peroxidation interventions preserve NE morphology and delay cell senescence in normal and HGPS cells
[PubMed: 23601421] 82
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