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In HG-induced models of human renal cortical epithelial cells (HRCApiC) and human renal proximal tubular epithelial cells (HRPTEpic), metformin restored Parkin protein expression and mitophagy through protein phosphatase (PP2A) activation, and inhibited NF-B activation, thereby reducing apoptosis of human renal epithelial cells under high glucose conditions [142]

22 The current proof-of-concept study was designed to evaluate whether (in)GSH is capable of augmenting CNS GSH concentrations, as measured by 1 H-MRS

L-Carnitine increases fat burning in mitochondria, a process which in turn decreases reliance on the glucose stores of the body

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