Specifically, we first prepared the intermediates, including Fmoc-CS, Fmoc-HDA and Fmoc-BSO, by modifying the disulfide bond linker, the control non-GSH responsive carboncarbon bond linker and BSO with 9-fluorenylmethyloxycarbonyl (Fmoc) group and succinic anhydride through liquid-phase reactions (Additional file 1: Figs
Avoid large, heavy meals on injection day
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10.1158/0008-5472.CAN-04-1567 83 HidaK.OhgaN.AkiyamaK.MaishiN.HidaY
( a, e, j ) Gold-standard Fourier Shell Correlation (FSC) curves for the consensus map (a), conformer 1 (e), and conformer 2 (j) showing overall nominal resolutions of 2.3 , 2.4 , and 2.5 , respectively
Your provider may recommend a series of injections over a few weeks for optimal outcomes