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These findings paved the way for the phase III STEP (Semaglutide Treatment Effect in People with obesity) program, which is currently investigating body weight changes following treatment with once-weekly 2.4 mg subcutaneous semaglutide ( 2 or BMI 27 kg/m 2 with at least one weight-related comorbidity (hypertension, dyslipidemia, obstructive sleep apnea, or CVD), while patients in STEP 2 had to have a BMI 27 kg/m 2 and T2D

Functional mechanism: Metal chelation by MT-1 peptide MT-1 achieves three core functions through metal chelation: Metal ion homeostasis regulation Zinc metabolism: MT-1 is the main storage reservoir of zinc within cells