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Phase 2b doses were 0.25 to 1.0 mg daily, which at a 2.5 mg/ml concentration means 0.1 to 0.4 ml per injection, conveniently measurable on a 1 ml insulin syringe

Combining pyridoxine with semaglutide enhances patient comfort during the initial weeks of therapy and also facilitates smoother dose escalation while minimizing GI-related side effects