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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice
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A small number of participants did experience transient skin irritation or mild discomfort at the injection site, but discontinuations due to these reactions were extremely rare
394:39-50 [PubMed: 31186120] 378
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