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Chronic inflammation is sustained by a lack of Notch signaling leading to toll-like receptor stimulation with subsequent TNF- and IL-1 secretion causing dendritic cell activation and IL-23 release which polarizes Th17 cells and leads to increased IL-17

Results: The use of GLP-1RAs have shown promising anti-inflammatory effects and improvement in wound healing, psoriasis, and hidradenitis suppurativa

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Dopamine agonists (FDA-approved pramipexole, ropinirole, or rotigotine) are effective but carry risks of augmentation (paradoxical worsening of symptoms) and impulse control disorders with long-term use

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When Wegovy launched, analysts predicted that treating obesity upfront would prevent more expensive interventions later, pushing insurers toward broader coverage