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Survodutide Timeline Boehringer Ingelheims SYNCHRONIZE program includes multiple Phase 3 trials: SYNCHRONIZE-1: Obesity without type 2 diabetes (726 participants, 76 weeks) SYNCHRONIZE-2: Obesity with type 2 diabetes (755 participants, 76 weeks) SYNCHRONIZE-CVOT: Cardiovascular outcomes (4,935 participants target) LIVERAGE trials: MASH-specific studies initiated October 2024 FDA Breakthrough Therapy designation for MASH may accelerate review for that indication specifically

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Furthermore, GRADE criterion was also applied to determine the effect certainty of estimated results

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Neurotoxicol Teratol 60:223 De Simone R, Ramacci MT, Aloe L (1991) Effect of acetyl-l-carnitine on forebrain cholinergic neurons of developing rats