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Shin JW, Wang JH, Kang JK, Son CG

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Regarding supplementation duration, most studies indicate that at least 412 weeks are required to observe significant effects

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The following represents a theoretical ultra-conservative approach based on monotherapy principles: Hypothetical Ultra-Conservative Schedule: This extended 24-week titration period doubles the typical monotherapy escalation timeline , reflecting the complete absence of interaction data and the overlapping side effect profiles