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For the rest of the 1980s, the work he had done to find exendin-1 and exendin-2 lay just as dormant as the wasp hive that once adorned John Pisanos office at the NIH

Switching between GLP1 receptor agonists in clinical practice: Expert consensus and practical guidance

Patients may notice nausea during the first few weeks

Like any medication, and like all GLP-1 agonists, tirzepatide can have side effects

Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access $199.00 per year only $3.83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature 653 , 680-681 (2026) doi: References Wilding, J

R., & Tschp, M