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As an outcome, metformin treatment restores spine density, surface GluA1 trafficking, long-term potentiation expression, and spatial memory (Wang et al., 2020c)

- Like any therapeutic agents, there may be side effects

KPV Mechanistic data on NF-B pathway suppression

With regards to monounsaturated fatty acids, similarly SAM-2 and BCV were most rich in oleic (peak 122) (12 mg/g), eicosenoic (peak 131) (0.71 mg/g) and docosenoic acids (peak 138) (3.3 and 0.2 mg/g), with the latter reported to possess antioxidant and anti-inflammatory effects 25

For laboratory research protocols, dose-finding studies in cell or animal models should always be designed based on the specific research question and validated reference literature

Novo Nordisk plans to file for FDA approval in early 2026