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Weight loss medications including GLP-1s (semaglutide, tirzepatide) produce dramatic VLDL improvements as patients lose significant weight and reverse metabolic dysfunction

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At the radius, trabecular vBMD declined, whereas cortical vBMD increased, potentially reflecting reduced cortical porosity

51, 52, 53 In the small intestine, GPBAR1/TGR5 activation could favorably modulate insulin sensitivity and glucose metabolism through stimulating the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) by ileal enteroendocrine L cells

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