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Importantly, primary human ILC2s exhibited conserved NRF2 activation, glutathione accumulation, and reduced type 2 cytokine production in response to melatonin, underscoring clinical relevance

Reduces Oxidative Stress : Restores the balance between free radicals and antioxidants to support overall skin resilience

Using both isn't overkill it's layered effectiveness, provided the percentages are appropriate (low in the cleanser, moderate in the leave-on)

C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1

Protein and lipid peroxidation products generated by oxidative stress in keratinocytes contribute to skin barrier dysfunction and exacerbate the progression of AD (42)

Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S et al (2010) Iodine intake as a determinant of thyroid disorders in populations