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US nativity and dietary acculturation impact the gut microbiome in a diverse US population

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FIGURE 1 Sufficiently high concentrations of dietary phenolic compounds at their site of action in tissues and organs trigger cellular events, e.g., at receptors, ion channels, transporter proteins, enzymes, or modulation of DNA transcription

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However, if the concentration of a metabolite that is distal to the metabolic reaction is expressed as a ratio to a metabolite that is proximal to the metabolic reaction, that ratio may reveal a change in that pathway that could otherwise go undetected