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These mechanisms appear to govern the various benefits of agmatine supplements, such as reducing blood pressure, expanding blood vessels, increasing beta-endorphin release, enhancing insulin sensitivity, boosting cognitive function, and inhibiting oxidative stress in neurons

This review aims to outline the relevant mechanisms of ferroptosis, its implications in the bone microenvironment, and the mechanisms of action and therapeutic perspectives of ferroptosis in common bone and joint diseases, with the goal of informing future clinical research and treatment strategies targeting ferroptosis under these conditions

According to the specific oxidation position, the 12/15-LOX is in charge of catalyzing AA to 12-/15- hydroperoxyeicosatetraenoic acid (12-/15-HpETE) (Snodgrass and Brune, 2019)