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One fundamental challenge for arthritis research is to identify specific, sensitive, and reliable biomarkers to detect these diseases in their early stages

109 , with the modification that no Matrigel was added after day 40 of differentiation to medium IDM + A (1:1 of DMEM/F12 and Neurobasal, 0.5% N2 supplement, 2% B27 +vitamin A, 0.25% insulin solution, 50 M 2-mercaptoethanol, 1% Glutamax, 0.5% MEM-NEAA, 1% penicillin-streptomycin, 0.4 mM vitamin C, and 1.49 g HEPES per 500 ml)

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It is essential to inform your prescribing clinician about all supplements you are taking or considering, including L-carnitine

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doi:10.1002/14651858.CD007321.pub2