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Indeed, there are case reports of monozygotic twins harboring the exact same mutation, both with elevated serum very long chain fatty acids (indicating a similar metabolic defect of peroxisomal lipid processing), where one boy is affected clinically and radiologically, while his twin brother is completely normal (Korenke et al., 1996)

(I) Des--carboxy prothrombin (DCP) is secreted from HCC cells and activates c-Met because it contains two structural regions that are similar to HGF (Suzuki et al., 2005

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