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The enzyme 4-phosphopantetheinyl transferase catalyzes the hydrolysis of coenzyme A to 3,5-adenosine diphosphate and 4-phosphopantetheine, and the transfer of the 4-phosphopantetheinyl moiety to a serine residue at the active site of ACP, converting biologically inactive apo-ACP into active holo-ACP

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Clin Cancer Res (2013) 19(24):674150

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We model the impact of AOMs over the next 20 years to 2045 with reference to three key groups of assumptions: effectiveness, uptake, and relative risk of mortality and morbidity