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Consistently, NAC and cysteine have also been shown to enhance Cu 2+ reduction and copper-induced proteotoxic stress, 168 suggesting that thiol-rich reducing environments can, under specific conditions, contribute to cytotoxicity

Furthermore, PX-12 regulates metastasis of colon cancer cells by diminishing the expression of vascular endothelial growth factor and attenuating hypoxia-inducible factor 1 subunit alpha (HIF1A) levels [227]