The Pearson correlation coefficient between thumb pressure tender point counts and dolorimetry pressure thresholds was 0.862 (explained variance = 0.742)
When faced with such a prospect, a 24-h clear liquid diet does not seem to pose an equal risk or inconvenience. The bottom line is this: the most risk-mitigating approach based on the evidence would be to have patients fast for longer (ideally no solids for 24 hours and no liquids for perhaps longer than 2 hours)
Oral GLP-1s and New Formulations: The December 2025 approval of oral semaglutide (Wegovy pill) and the anticipated approval of orforglipron (Eli Lilly's non-peptide oral GLP-1) in 2026 will expand the patient pool significantly
Identifying likely responders in advance could help patients reach the most effective therapy sooner and move diabetes care closer to precision medicine, she said
External resources Phase 2 clinical trial: Once-weekly cagrilintide for weight management (The Lancet) REDEFINE 1: Coadministered cagrilintide and semaglutide (NEJM) Systematic review: Efficacy and safety of cagrilintide alone and in combination (PMC) For researchers serious about navigating cagrilintide protocols safely, SeekPeptides provides comprehensive, evidence-based guides, dosing tools, and a community of experienced researchers who have worked through these exact questions
Adderall suppresses appetite mildly, which stacks with GLP-1
