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Patients who are pregnant, planning pregnancy, or breastfeeding must not use it

Moreover, induction of p38 and NF-kappa B pathways can occur through ER stress, exacerbating inflammatory responses [187]

Studies consistently show 10 to 30 percent of metformin users develop low b12 levels over years of use

Ann Surg 256(4):642-50, 2012

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