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At physiological pH 7.4, only 5% of GSH is in the active deprotonated form, making it not very reactive in the cellular environment [102]

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J Chromatogr B Analyt Technol Biomed Life Sci 1221:123688 Lim JY, Kim TH, Song CH, Kim D-H, Shin BS, Shin S (2022) Novel extended IVIVC combined with DoE to predict pharmacokinetics from formulation compositions

For others, it may be simply an expense that doesnt meaningfully improve health or financial outcomes