Seu mecanismo de ao ocorre principalmente pela ativao da AMPK (protena quinase ativada por monofosfato de adenosina), o que leva inibio da gliconeognese heptica e consequente reduo da produo de glicose pelo fgado, sem estimular a secreo de insulina e, portanto, evitando a hipoglicemia (ZHOU et al., 2001
Baseline glycemic control : Patients with higher HbA1c levels may require more aggressive dose escalation, though this must be balanced against tolerability
It is an investigational drug in active Phase 3 trials
Recommended conditions for lyophilized GLP-1S are: Room temperature (unopened, lyophilized): Suitable for short periods when kept sealed, dry, and protected from light
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He later completed a Master of Business Administration with an emphasis in health care administration at Ohio University