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Factors such as rectal irritation, lesions, or recent surgery may affect the suitability of this route of administration

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CINCA/NOMID manifests early in life with a non-pruritic rash, aseptic meningitis, deforming arthropathy, skeletal abnormalities, and distinctive facial features such as frontal bossing and saddle-nose deformity (70)

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In embryo culture and selection, multimodal models that combine morphokinetics with non-invasive molecular readouts may add value when conventional assessment is uncertain or discordant [436, 479, 480]