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SURMOUNT-3, combining tirzepatide with intensive lifestyle intervention, demonstrated 26.6% total weight loss
When you compare this to Mounjaro, where clinical trials have shown patients can lose up to 22.5% of their body weight after 72 weeks, the difference in the level of evidence is significant
Second, improvements in IR and glycaemic indices are most apparent in higher-burden phenotypes, particularly in women with impaired glucose tolerance/prediabetes or related metabolic comorbidities, where changes in HOMA-IR, fasting glucose and OGTT profiles are more pronounced and may plausibly reduce periconception metabolic risk
These findings solidified liraglutide as a valuable therapy for T2DM for individuals seeking weight management and a lower risk of hypoglycemia (35)
DOI: 10.1186/1550-2783-11-20