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Interestingly, supplementation of metformin with 1.5 mg dulaglutide per week in the treatment of T2MD in obese patients with severe impairment of glycosylated hemoglobin A1c (HbA1c) was reported to bring lasting benefits in the control of glucose metabolism and body weight (173)

The semaglutide observational data suggests GLP-1 agonists may reduce smoking independent of their metabolic effects

Some of the most common side effects in clinical trials included nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion (dyspepsia), and stomach (abdominal) pain

For instance, the SELECT trial reported a 20% reduction in major adverse cardiovascular events among participants using Semaglutide compared to a placebo

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