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Even so, each increase can temporarily trigger semaglutide side effects such as diarrhea before the system settles

In the Phase III NefIgArd trial, patients treated with Tarpeyo saw significantly better kidney function, as measured by the estimated glomerular filtration rate (eGFR) versus placebo after nine months on the drug and 15 months of follow-up

Additionally, preclinical animal models provide mechanistic insights but may not fully translate to human physiology, particularly in conditions such as osteoporosis, obesity-related bone changes, and joint infections