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Reductions in proinflammatory cytokines such as IL-17, IL-23, and TNF- as detected by protein expression levels in immunohistochemistry, alongside histological improvements in epidermal thickness, support this anti-inflammatory mechanism

Another study, the EXAMINE trial, investigated alogliptin medication in individuals with Type 2 diabetes who had experienced acute coronary syndrome and revealed no increase in major adverse cardiovascular events

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KDOQI clinical practice guideline for nutrition in CKD: 2020 Update