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The cardioprotective effects of metformin may date back to over two decades ago, when UKPDS 34 confirmed the reduction of diabetes-related complications, including the risk of cardiovascular events and CV death among overweight T2DM patients [13]
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However, Semaglutide remains a strong alternative, particularly for those who respond well to GLP-1 therapies or prefer its availability for weight loss under FDA approval
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