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SI, RU, and MM wrote the draft manuscript, which was edited by MI and NN

suggested to help learning, mood and memory in animal research.(21) CoQ10 - coenzyme pseudo-vitamin that helps brain health by powering up brain cell mitochondria and supplying anti-aging antioxidant activity.(22) Creatine - Creatine supplementation is popular among athletes looking to charge-up their muscles, may work in the same way in the brain to enhance mental energy.(23) Choline - similar to B vitamins and related to lecithin, it declines with age but is important for brain chemical acetylcholine and maintaining healthy brain structure.(24) DHA (Omega-3 fatty acids) - essential fatty acid that supports brain function and is crucial for early brain development and helpful for sharp cognition in old age.(25) DMAE - found in sardines, helps to optimize brain cell structure and has been suggested to help with attention, mood and cognitive decline.(26) Forskolin - active ingredients of Coleus Forskohlii, promotes cAMP molecules that helps regulate cell to cell communication, mood and memory storage.(27) GABA - inhibitory amino acid that settles nerves producing relaxation and pleasant mood, suggested to help with sleep and potentially attention.(28) Ginkgo biloba ancient Chinese wellness herb enhances brain circulation, strong reputation for helping with memory and age-related cognitive performance.(29) Ginseng - adaptogen herb that supports brain chemicals and cAMP while countering stress

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In different tumor types, the accumulation of specific metabolites (called oncometabolites) has been reported, especially concerning three intermediates derived from the Krebs cycle, i.e., 2-hydroxyglutarate (2-HG), succinate, and fumarate

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