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It is used in postmenopausal women with hormone receptor-positive breast cancer

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42:51-55 (2004) Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM

Safety is paramount, and prescribing should only ever be undertaken by appropriately qualified doctors.

and maintained at atmospheric oxygen levels and 5% CO 2

The upregulation of Sirt3 protects against impaired electron transport and ATP production, loss of mitochondrial membrane potential (MMP) and neuronal vulnerability, and treatment with Sirt3 agonists can restore mitochondrial integrity, reduce S oligomers and oxidative stress