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Igncio, Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression, Front

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Goovaerts G, Buyssens N

doi: 10.1159/000297775

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Here, we confirm the GIPR antagonist and GLP-1R agonist activities in cell-based systems and report the ability of AMG 133 to reduce body weight and improve metabolic markers in male obese mice and cynomolgus monkeys