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Upon cell internalization via endocytosis mechanisms, these nanoparticles disrupt endosomal membranes through the proton sponge effect, facilitating the intracellular delivery of exogenous nucleic acids

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Based on available Phase 2 data, both agents share a side-effect profile broadly consistent with other medicines acting on metabolic hormone pathways, though the triple-agonist mechanism of retatrutide introduces some additional considerations

Rand EED, Smit S, Beukes M, Apostolides Z, Pirk CWW, Nicolson SW