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Analytical verification methods are applied to confirm peptide identity, chemical purity, and batch consistency across production lots

Retatrutide and tirzepatide are typically supplied at higher concentrations than 1 mg/ml after reconstitution, so the unit math is different from semaglutide

Dosing Phases, Titration & Cycling The documented GLOW research schedule is a three-phase frequency taper rather than a dose-size titration

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Comment: Commenters requested that CMS eliminate or waive the productivity adjustment for CY 2026 and going forward using CMS' special exceptions and adjustments authority under section 1886(b)(3)(B)(xi) of the Act, which would justify special circumstances

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