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Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

And BPC-157 protected against all three

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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Alkhouri N., Herring R., Kabler H., Kayali Z., Hassanein T., Kohli A., Huss R.S., Zhu Y., Billin A.N., Damgaard L.H., et al