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Limitations: caffeine wont produce long-term weight loss by itself - it only supports workout intensity and short-term fat oxidation

GLP-1 receptors exist not just in your gut but also in your brain, particularly in the areas tied to reward and motivation

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Candidates for supervised discontinuation: Maintained goal weight on a stable dose for 12 or more months Lost weight primarily through combined medication and lifestyle change (not medication alone) Consume 1.2 to 1.6 g protein per kg body weight daily Perform resistance training 3 or more times per week Sleep 7 or more hours nightly with good sleep architecture Have a BMI at goal of 25 or higher (patients who drop into the low-normal range have less metabolic buffer) No history of binge eating disorder or significant emotional eating patterns Even with this profile, the SURMOUNT-4 data suggests that roughly half of patients will regain meaningful weight within 12 months of stopping (Aronne et al., JAMA 2024)