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Metabolism 14 (6), 531538

[PubMed: 15763695] 48

Preclinical studies showed that indeed, the Nottingham group was on the right track

Symptoms usually peak during dose escalation and diminish with continued therapy at stable doses

it has not been tested in a human clinical trial

With respect to definition of controls, most studies recruited healthy children with no information about family history of autism spectrum disorders, although, four studies did ensure that controls did not have either a family history or sibling with autism [70, 75, 77, 87] and one screened for autism traits [59]