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To test whether the regulation of CYP8B1 by T3 would have any effect on BA composition, we performed UFLC-Triple-time of flight/MS-based metabolite profiling to quantitate the BA levels and found that the percentage of 12-hydroxylated (12-OH) BAs was reduced, while the proportion of non-12-hydroxylated (non-12-OH) BAs was increased in the gallbladder bile, ileum, liver, serum, and urine after five days of T3 treatment in MMI mice (Fig

European Medicines Agency

The STEP-1 trial that established semaglutide for weight management capped doses at 2.4 mg weekly and produced 14.9% mean body-weight loss over 68 weeks (Wilding et al., 2021)

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Some beneficial bacteria produce metabolites that may stimulate L-cells

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