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In the gastrointestinal tract, GLP-1R reduces gastric acid secretion, slows gastrointestinal motility, delays gastric emptying, and increases satiety, thereby aiding weight management

Accidental injection of high dose (1:1,000) epinephrine contained in epinephrine autoinjectors into fingers or thumb can produce prolonged tissue ischemia, reperfusion pain, and in some cases traumatic nerve injury (neuropraxia) lasting as long as 8-10 weeks (Fitzcharles-Bowe et al, 2007

The vasodilatory effect of liraglutide seems to wane in more advanced chronic kidney disease

What happens over months and years of use matters far more for lasting health outcomes

Acknowledgements The authors would like to thank the biotechnicians at the Small Animal Centre of Wageningen University (Wageningen, the Netherlands) for excellent assistance

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