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Given that CV complications remain a leading cause of morbidity and mortality in people with T2D (266), despite substantial efforts to reduce risk using CV medications, the availability of antidiabetes medications that can contribute to risk reduction is a significant advance

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These similarities with our model carrying TrKB depletion in iSPNs suggest a new concept for BDNFTrkB signalling in the context of striatal protection modulating dopamine circuits through metabolic pathways such as glutathioneascorbate and energy metabolism

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