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Changes in the expansion of polymorphonuclear precursors to granulocyte-colony stimulating factor (G-CSF) have been observed in elderly individuals [124], although responses to other stimulants like IL-3 and granulocytemacrophage colony stimulating factor (GM-CSF) remain unchanged, ensuring sufficient neutrophilia during infection [125, 126]

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This study aimed to address this knowledge gap by assessing the comparative effectiveness of these medications approved for obesity management among US adults with the disease of obesity, without diabetes in routine care settings

Higher doses are associated with improved outcomes in weight loss and glycemic control