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Instead, variant patterns in these pathways can illuminate metabolic predispositionssuch as genetic appetite-regulation architecture or lipid-metabolizing capacitythat may inform whether a structured metabolic coaching model (like Calibrate's) or a more autonomous telehealth approach (like Ro's) aligns better with a patient's biological and behavioral needs

The variation reflects individual starting doses and metabolic differences

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nejm.org SURMOUNT-1 tirzepatide trial, New England Journal of Medicine (Jastreboff et al., 2022)