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These observations indicate that DMFs activation of NRF2 originates not only from inducing NRF2 in the cytoplasm but also from inhibiting the NRF2 repressor in the nucleus

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Rare side effects include stomach paralysis, inflammation of the pancreas or an obstruction in the small bowel

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In cancer cells, TrxR1/2 inhibition by Hdy-7 induces cytotoxic autophagy through elevated ROS and TFEB activation, which can be reversed by antioxidants or p53 knockdown, illustrating the redox sensitivity of this pathway