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Regarding explanations behind the findings, it is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brains reward system, Markku Lhteenvuo , PhD, a study co-author and research director at the University of Eastern Finland, said in the release

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These disruptions interfere with clearance mechanisms involving substrate engulfment, autophagosome formation, autophagosome-lysosome fusion, and lysosomal structure and function