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Acidosis is due to reduced feedback inhibition of -glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline

The authors emphasize that interpreting preclinical tumor progression data requires caution, as mechanisms affecting incidence may not accurately predict tumor behavior once established

The diagnostic process itself is clear-cut

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But like any medication, GLP-1s carry a few risks alongside their benefits