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Moreover, in a meta-analysis of 27 randomized controlled trials with an average duration of 64 weeks that compared the efficacy and safety of SGLT2 inhibitors to a placebo in 20,895 participants there was no increased risk of fractures with SGLT2 inhibitor treatment (RR 1.02

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The NHS recommends a structured approach combining a balanced calorie-controlled diet, at least 150 minutes of moderate-intensity physical activity per week, and behavioural support such as the free NHS 12-Week Weight Loss Plan

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