GLP-1 receptor agonists are a class of medications originally developed and licensed for the treatment of type 2 diabetes mellitus, with some formulations also approved by the MHRA for weight management in adults with obesity or overweight with weight-related comorbidities, under specialist services as per NICE guidance (TA875)
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Other Potential Side Effects to Watch Gastroparesis (stomach paralysis) Can cause early fullness, bloating, or rare intestinal blockages
Overall discontinuation rates remained similar across treatment groups
Trials on Zepbound found that 0.1% of patients had a severe hypersensitivity reaction (such as anaphylaxis) compared to 0% in the placebo group
Source reviewed What to check before choosing Compounded Semaglutide FormBlends medical team | May 29, 2026 Readers searching for segulatide need a direct answer first, then the details that could change the decision