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Common gastrointestinal side effects (nausea, bloating) may make rich or sweet foods less appealing during treatment

Semaglutide's extended half-life (approximately 7 days) means the medication accumulates in the bloodstream with each weekly injection, creating prolonged effects on blood pressure and fluid balance compared to shorter-acting GLP-1 agonists

doi: 10.2337/dc14-S081 6 NekouaMPAlidjinouEKHoberD

In a post hoc analysis of the SUMMIT trial, the decrease in estimated blood volume seen in participants treated with tirzepatide was significantly correlated with decreased blood pressure, lower microalbuminuria, improved KCCQ-CSS, and greater 6-min walking distance [85]

The side effects outlined above arent comprehensive