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Additionally, we did not grade comorbid conditions at baseline, which might have caused some selection bias in the cohorts

This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

doi: 10.1016/S0140-6736(18)31773-2, 112 OngZ

The article says screening should complement rather than replace a full medical evaluation

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