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These challenges can involve internal factors such as hormonal influence on the homeostatic regulation of body weight [11]

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Treatment with GLP-1 RAs has been associated with improved insulin sensitivity, as reflected by reductions in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores, and these changes often align with improvements in psoriasis severity

Furthermore, higher levels of leptin in children with obesity may lead to CNS stimulation that also impacts the onset of puberty

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